| 外消旋化合物生物催化去对称化研究进展 |
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| 引用本文： | 苏亚民,戴大章. 外消旋化合物生物催化去对称化研究进展[J]. 分子催化, 2021, 35(5): 471-483 |
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| 作者姓名： | 苏亚民 戴大章 |
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| 作者单位： | 北京理工大学,北京理工大学 |
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| 基金项目： | 国家自然科学基金(21276025, 21808004) |
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| 摘 要： | 手性化合物外消旋体的生物催化去对称化是目前生物与有机合成领域的重点、难点和热点,也是制备光学纯手性化合物的重要途径.我们将近年来发展起来的手性化合物生物催化去对称化的方法归纳为立体转化去对称化法、线性去对称化法、循环去对称化法、对映体收敛去对称化法和一步去对称化法5大类,对这些方法的原理、特点及其应用进展分别进行介绍,...
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| 关 键 词： | 手性化合物 外消旋体 生物催化 去对称化 |
| 收稿时间： | 2021-06-10 |
| 修稿时间： | 2021-07-01 |
Research Progress in Biocatalytic Desymmetrization of Racemic Compounds |
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| SU Ya-min and DAI Da-zhang. Research Progress in Biocatalytic Desymmetrization of Racemic Compounds[J]. Journal of Molecular Catalysis (China), 2021, 35(5): 471-483 |
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| Authors: | SU Ya-min and DAI Da-zhang |
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| Affiliation: | Beijing Institute of Technology,Beijing Institute of Technology |
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| Abstract: | The biocatalytic deracemisation of racemates of chiral compounds is currently the focus, difficulty and hotspot in the field of biological and organic synthesis, and it is also an important way to prepare optically pure chiral compounds. In this paper, the methods for biocatalytic deracemisation of chiral compounds developed in recent years are summarized as deracemisation by stereoinversion method, linear deracemisation method, cyclic deracemisation method, enantioconvergent process method and one-step deracemisation method. The principles, characteristics and application progress of these five categories of methods are respectively introduced and their future development trends are prospected. |
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| Keywords: | chiral compounds racemates biocatalysis deracemisation |
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