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Mechanochemical synthesis of hemin–imidazole complexes |
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| Authors: | Paneque Armando Fernández-Bertran José Reguera Edilso Yee-Madeira Hernani |
| Affiliation: | (1) Center of Pharmaceutical Chemistry, Havana, Cuba and Center for Applied Science and Advanced Technology of IPN (CICATA-IPN), Legaria 694, Col. Irrigacion, 11500 Mexico, D.F., Mexico;(2) Center for Applied Science and Advanced Technology of IPN (, CICATA-IPN, Legaria 694, Col. Irrigacion, 11500 Mexico, D.F., Mexico;(3) Institute of Materials and Reagents, Havana University, Cuba;(4) School of Physics and Mathematics of, IPN, Col. indavista, Mexico, D.F., Mexico |
| Abstract: | Solid state reactions of hemin and imidazole were performed by milling the crystalline materials in an agate mortar. The process was monitored by i.r., x.r.d. and Mössbauer spectroscopies. Samples with different hemin to imidazole molar ratios were studied. The interactions of imidazole with the central Fe atom and with the propionic acid groups in the periphery of the hemin molecule were detected. The latter interactions are suppressed by washing with MeOH. Complexes with 1:2 and 1:4 hemin-to-imidazole molar ratios were identified. |
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