RNAA for arsenic,cadmium, copper,and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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RNAA for arsenic,cadmium, copper,and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

Authors:	L Tandon B -F Ni X X Ding W D Ehmann E J Kasarskis W R Markesbery

Institution:	(1) Department of Chemistry, Unviersity of Kentucky, 40506 Lexington, KY, USA;(2) Department of Neurology, University of Kentucky, 40506 Lexington, KY, USA;(3) Department of Pathology, University of Kentucky, 40506 Lexington, KY, USA;(4) Graduate Center for Toxicology, University of Kentucky, 40506 Lexington, KY, USA;(5) Sanders Brown Center on Aging, University of Kentucky, 40506 Lexington, KY, USA

Abstract:	Reactor thermal neutron irradiation of biological matrices induces high levels of intense gamma-ray or bremsstrahlung radiation from⁸²Br,⁴²K,²⁴Na, and³²P, that interfere with the determination of As, Cd, Cu, and Mo by INAA. Central nervous system (CNS) issue samples from subjects with Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and controls were analyzed using a simple RNAA procedure involving a rapid two-step solvent extraction procedure to determine these four elements. Significant increases (p0.05) in concentrations of Cd and Mo were observed for brain of AD subjects compared to controls, but significant imbalances were not observed for ALS subjects. Concentration data for these elements in selected international reference standards are also presented.

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