| 见血封喉根中类黄酮的结构鉴定 |
| |
| 引用本文： | 阙东枚,梅文莉,吴娇,韩壮,戴好富,Haofu. 见血封喉根中类黄酮的结构鉴定[J]. 有机化学, 2009, 29(9): 1371-1375 |
| |
| 作者姓名： | 阙东枚 梅文莉 吴娇 韩壮 戴好富 Haofu |
| |
| 作者单位： | 中国热带农业科学院热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海口,571101 |
| |
| 基金项目： | 国家自然科学基金，中央级公益性科研院所基本科研业务费专项资金，海南省自然科学基金 |
| |
| 摘 要： | 从海南产见血封喉[Antiaris toxicaria (Pers.) Lesch.]根的乙醇提取物中分离得到8个黄酮类化合物, 分别鉴定为antiarones K, B, F～I (1～6), (±)-sigmoidin A (7)和2-[2,3-二氢-4-羟基-2-(2-羟基-2-丙基)-5-甲氧基-1H-茚基]-1-(2,4,6-三羟基苯基)乙酮(8). 其中antiarone K (1)为新的异戊烯基二氢黄酮. 运用现代波谱技术, 包括二维核磁共振谱和高分辨质谱, 对上述化合物的结构进行了确证. 以上化合物经滤纸片法进行抗菌活性测试, 结果表明化合物1和3均具有抗金黄色葡萄球菌活性, 化合物3还具有抗耐甲氧西林金黄色葡萄球菌(MRSA)活性; 经MTT法进行细胞毒活性测试, 结果表明化合物1和6～8对慢性髓原白血病细胞(K562)、人胃癌细胞(SGC-7901)和人肝癌细胞(SMMC-7721)的增殖显示了生长抑制活性.
|
| 关 键 词： | 见血封喉 异戊烯基二氢黄酮 Antiarone K 抗菌活性 细胞毒活性 |
| 收稿时间： | 2008-12-24 |
| 修稿时间： | 2009-02-20 |
Structure Elucidation of Flavonoids from Antiaris toxicaria Roots |
| |
| Que,Dongmei Mei,Wenli Wu,Jiao Han,Zhuang Dai,Haofu. Structure Elucidation of Flavonoids from Antiaris toxicaria Roots[J]. Chinese Journal of Organic Chemistry, 2009, 29(9): 1371-1375 |
| |
| Authors: | Que Dongmei Mei Wenli Wu Jiao Han Zhuang Dai Haofu |
| |
| Affiliation: | (Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101) |
| |
| Abstract: | A new prenylflavanone, antiarone K (1), together with seven known flavonoids, antiarones B, F～I (2～6), (±)-sigmoidin A (7), and 2-[2,3-dihydro-4-hydroxy-2-(2-hydroxy-2-propyl)-5-methoxy-1H- inden-1-yl]-1-(2,4,6-trihydroxyphenyl)ethanone (8), was isolated from the ethanolic extract of the roots of Antiaris toxicaria (Pers.) Lesch collected from Hainan. The structures were established by spectroscopic methods (IR, 1D-, 2D-NMR, and HR-ESIMS). Compounds 1 and 3 possessed inhibitory effects on Staphy-lococcus aureus, and compound 3 possessed inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) as shown by the filter paper disc diffusion method. Compounds 1, 6～8 showed inhibitory activity towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines by MTT assay. |
| |
| Keywords: | Antiarone K |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
|
点击此处可从《有机化学》下载全文 |
|
