An observation of unusual temperature effects for enantioselective CZE employing highly sulfated-beta-cyclodextrin |
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Authors: | Westall Anne Malmström Torsten Petersson Patrik |
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Affiliation: | Analytical Development PAR&D, AstraZeneca R&D Lund, Lund, Sweden. Anne.Westall@astrazeneca.com |
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Abstract: | In this paper data are presented suggesting that for enantiomers of basic and neutral analytes, the concentrations of highly sulfated CDs typically used are above the optimum since lower concentrations result in unacceptable migration times. This situation arises because of the high binding affinities often obtained with sulphated CDs. In a system being over the optimum CD concentration increasing the temperature of the capillary offers a capability to improve selectivity and reduce migration times. |
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