| Convenient synthesis of （4R,5R）-4,5-bis（aminomethyl）-2-isopropyl- 1,3-dioxolane |
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| 引用本文： | Jian Jiang De Cai Wang Wei Lin Ping Kai Ouyang. Convenient synthesis of （4R,5R）-4,5-bis（aminomethyl）-2-isopropyl- 1,3-dioxolane[J]. 中国化学快报, 2007, 18(7): 783-784. DOI: 10.1016/j.cclet.2007.05.035 |
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| 作者姓名： | Jian Jiang De Cai Wang Wei Lin Ping Kai Ouyang |
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| 作者单位： | Jian Jiang，De Cai Wang *，Wei Lin，Ping Kai Ouyang College of Life Science and Pharmaceutical Engineering，Nanjing University of Technology，Nanjing 210009，China |
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| 摘 要： | A convenient approach for the preparation of (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane is described. The target compound via two steps is synthesized from diethyl-2,3-O-isobutylidene-D-tartrate, through ammonolysis and reduction.
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| 关 键 词： | 合成 抗癌药物 氨甲基 中间体 二恶茂烷 |
| 收稿时间： | 2007-02-26 |
| 修稿时间： | 2007-02-26 |
Convenient synthesis of (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl- 1,3-dioxolane |
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| Jian Jiang,De Cai Wang,Wei Lin,Ping Kai Ouyang. Convenient synthesis of (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl- 1,3-dioxolane[J]. Chinese Chemical Letters, 2007, 18(7): 783-784. DOI: 10.1016/j.cclet.2007.05.035 |
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| Authors: | Jian Jiang De Cai Wang Wei Lin Ping Kai Ouyang |
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| Affiliation: | College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China |
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| Abstract: | A convenient approach for the preparation of (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane is described. The target compound via two steps is synthesized from diethyl-2,3-O-isobutylidene-D-tartrate, through ammonolysis and reduction. |
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| Keywords: | Heptaplatin Aminomethyl Intermediate Anticancer drug |
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