Total synthesis of zincophorin and its methyl ester |
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| Authors: | Defosseux Magali Blanchard Nicolas Meyer Christophe Cossy Janine |
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| Institution: | Laboratoire de Chimie Organique, asocié au CNRS, ESPCI, 10 rue Vauquelin 75231 Paris Cedex 05 - France. |
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| Abstract: | A total synthesis of the naturally occurring ionophore zincophorin has been realized. The route features an intramolecular oxymercuration of a cyclopropanemethanol and a Carroll-Claisen rearrangement for the respective elaboration of the C1-C12 and C13-C25 subunits, which have been assembled by using a highly diastereoselective titanium-mediated aldol condensation. |
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