Metal-free, aerobic dioxygenation of alkenes using simple hydroxamic acid derivatives |
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Authors: | Giglio Benjamin C Schmidt Valerie A Alexanian Erik J |
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Institution: | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States. |
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Abstract: | The dioxygenation of alkenes using molecular oxygen and a simple hydroxamic acid derivative has been achieved. The reaction system consists of readily prepared methyl N-hydroxy-N-phenylcarbamate and molecular oxygen with a radical initiator, offering an alternative to common dioxygenation processes catalyzed by precious transition metals. This transformation capitalizes on the unique reactivity profile of hydroxamic acid derivatives in radical-mediated alkene addition processes. |
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