Thai plants from Doi Tung: brine shrimp lethality, antioxidative activity and combination effect with L-ascorbic acid |
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| Authors: | Tanamatayarat Patcharawan Sotanaphun Uthai Poobrasert Onoomar |
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| Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Mueang, Nakhon Pathom 73000, Thailand. |
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| Abstract: | Methanolic extracts of 18 Thai plants from Doi Tung, the north of Thailand, were examined for brine shrimp lethality and antioxidative activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In brine shrimp lethality, the highly toxic plant extracts were Mitrephora wangii (LC(50) 14.8?μg?mL(-1)) and Hydrocotyle javanica (LC(50) 13.3?μg?mL(-1)). The extracts of Sageretia cordifolia, Ulmus lancaefolia and Acer chiangdaoense exhibited highly antioxidative activities with IC(50) values of 6.7, 8.1 and 9.8?μg?mL(-1), respectively. Moreover, the extracts of S. cordifolia, U. lancaefolia and A. chiangdaoense have shown slightly synergistic effects (combination index; CI?
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