Kinetic preference for interaction of cisplatin with the G-C-rich wobble basepair region in both tRNAAla and MhAla |
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| Authors: | Papsai Pal Aldag Jasmin Persson Tina Elmroth Sofi K C |
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| Affiliation: | Biochemistry, Chemical Center, Lund University, SE-221 00 Lund, Sweden. |
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| Abstract: | The anticancer active complex cisplatin interacts preferentially with the common, G-C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex. |
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