Recent studies at Durham on direct fluorination |
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Authors: | Richard D. Chambers John Hutchinson Graham Sandford |
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Affiliation: | Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK |
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Abstract: | Developments in direct fluorination are described, which changed our perception of the viability of this methodology for selective introduction of carbon–fluorine bonds. Use of acids as solvent media is a valuable technique for electrophilic fluorination, especially with aromatic systems. Fluorinations of 1,3-dicarbonyl compounds proceed well and techniques for promoting reactivity in other carbonyl derivatives are described. ‘In-situ’ formation of other reagents, e.g. by reaction of fluorine with other halogens and with water, provides convenient methodology for halogenation and oxidation. |
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Keywords: | Fluorine Halogenation Oxidation Electrophilic fluorination |
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