| 嘧啶类酪氨酸激酶抑制剂 |
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| 引用本文： | 朱秀杰,刘丹,孔建,姜家妹,吕翠萍. 嘧啶类酪氨酸激酶抑制剂[J]. 化学通报, 2011, 74(6): 528-533 |
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| 作者姓名： | 朱秀杰 刘丹 孔建 姜家妹 吕翠萍 |
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| 作者单位： | 沈阳化工大学制药工程教研室; |
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| 摘 要： | 酪氨酸激酶在肿瘤的发生、发展过程中起着非常重要的作用,已成为肿瘤治疗的新靶点.嘧啶类化合物是蛋白酪氨酸酶抑制剂(PTKIs)中的一大类,这类化合物在临床前期研究中显示具有很好的抗肿瘤效应,一些已在临床上作为很有前景的抗癌药.本文按其结构类别介绍了近年来报道的嘧啶类酪氨酸激酶抑制剂.
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| 关 键 词： | 酪氨酸激酶抑制剂 嘧啶类化合物 抗肿瘤药物 |
Tyrosine Kinase Inhibitors of Pyrimidines |
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| Zhu Xiujie,Liu Dan,Kong Jian,Jiang Jiamei,Lv Cuiping. Tyrosine Kinase Inhibitors of Pyrimidines[J]. Chemistry, 2011, 74(6): 528-533 |
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| Authors: | Zhu Xiujie Liu Dan Kong Jian Jiang Jiamei Lv Cuiping |
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| Affiliation: | Zhu Xiujie,Liu Dan,Kong Jian,Jiang Jiamei,Lv Cuiping(Faculty of Pharmaceutical Engineering,Shenyang University of Chemical Technology,Shenyang 110142) |
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| Abstract: | Protein Tyrosine Kinase Inhibitors(PTKIs) play critical roles in the process of cancer development and have become new target for tumor treatment.Pyrimidines are one large class of PTKIs.They have shown good antitumor effect in preclinical studies.Some of them have been promising anti-cancer drugs in clinical use.The development of PTKIs of Pyrimidines is introduced according to their structures. |
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| Keywords: | Tyrosine kinase inhibitors Pyrimidines Antitumor drugs |
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