| 两种吲唑合成方法的改进 |
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| 引用本文： | 易奋飞,何毅.两种吲唑合成方法的改进[J].化学通报,2011(8):760-764. |
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| 作者姓名： | 易奋飞 何毅 |
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| 作者单位： | 西南石油大学化学化工学院; |
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| 摘 要： | 苯乙烯类吲唑衍生物是一类重要的类胰岛素生长因素1受体抑制剂。本文介绍了它的两种合成原料：6-氯-3-甲基吲唑和6-氟-3-羰甲基吲唑的合成方法,并对以邻卤苯羰基类化合物为原料生成苯腙再分子内环化和吲哚的重氮化反应这两种方法进行了改进。改进后的方法产率大大提高,反应时间缩短,后处理简化,更利于吲唑类化合物的大规模生产,对...
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| 关 键 词： | 分子内环化 重氮化反应 吲唑 |
The Improvement of Two Kinds of Synthetic Methods of Indazoles |
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| Yi Fenfei,He Yi.The Improvement of Two Kinds of Synthetic Methods of Indazoles[J].Chemistry,2011(8):760-764. |
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| Authors: | Yi Fenfei He Yi |
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| Institution: | Yi Fenfei,He Yi(College of Chemistry and Chemical Engineering,Southwest Petroleum University,Chengdu 610500) |
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| Abstract: | The styrene's derivatives of the indazole were a type of important IGF-1R inhibitor.In this article,the synthetic methods of two kinds of starting materials which are 6-chloro-3-methyl-1H-indazole and 6-fluoro-1H-indazole-3-carbaldehyde were introduced.And the methods of intramolecular cyclization of phenylhydrazine using o-halogen phenylcarbamoyl as starting materials and diazo-reaction of indole were improved.The improved methods made to raise the yield,shorten the reaction time and simplify the post-trea... |
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| Keywords: | Intramolecular cyclization Diazo reaction Indazole |
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