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Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress |
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| Authors: | Xinkun Wang Asma Zaidi Ranu Pal Alexander S Garrett Rogelio Braceras Xue-wen Chen Mary L Michaelis Elias K Michaelis |
| Affiliation: | (1) Higuchi Biosciences Center, University of Kansas, 2099 Constant Ave., 66047 Lawrence, KS, USA;(2) Department of Pharmacology and Toxicology, University of Kansas, 1251 Wescoe Dr., 66045 Lawrence, KS, USA;(3) Department of Biochemistry, Kansas City University of Medicine and Biosciences, 1750 Independence Ave., 64106 Kansas City, MO, USA;(4) Bioinformatics and Computational Life Sciences Laboratory, Department of Electrical Engineering and Computer Science, University of Kansas, 2335 Irving Hill Rd., 66045 Lawrence, KS, USA;(5) Stowers Institute for Medical Research, 1000 E 50th St., 64110 Kansas City, MO, USA;(6) Daiichi Sankyo Inc., Two Hilton Court, 07054 Parsippany, NJ, USA |
| Abstract: | BackgroundOxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the underlying mechanisms of this selective neuronal vulnerability. The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and biochemical approaches. |
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