Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential |
| |
Authors: | O'Neill Jennifer C Blackwell Helen E |
| |
Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA. |
| |
Abstract: | Diketopiperazines (DKPs) are a well-known class of heterocycles that have recently emerged as a promising biologically active scaffold. Solid-phase organic synthesis has become an important tool in the combinatorial exploration of these privileged structures, expediting the synthesis and, therefore, the discovery of active compounds. To date, certain DKPs have shown potent activities against a range of diseases and biological phenomena, including bacterial infections, various cancers, asthma, infertility, premature labor, and HIV. Recent applications of solid-phase DKP synthesis, with a particular focus on cyclative cleavage and microwave-assisted reactions, are highlighted herein. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|