Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects |
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| Authors: | Patrick Ragert Tobias Kalisch Barbara Bliem Stephanie Franzkowiak Hubert R Dinse |
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| Affiliation: | (1) Institute for Neuroinformatics, Department of Theoretical Biology, Experimental Neurobiology Lab, Ruhr-University, 44780 Bochum, Germany;(2) Department of Neurology, BG-Kliniken Bergmannsheil, Ruhr-University, 44789 Bochum, Germany;(3) National Institute of Neurological Disorders and Stroke, National Institutes of Health, Human Cortical Physiology Section, 20892 Bethesda, MD, USA |
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| Abstract: | Background Long-term potentiation (LTP) and long-term depression (LTD) play important roles in mediating activity-dependent changes in synaptic transmission and are believed to be crucial mechanisms underlying learning and cortical plasticity. In human subjects, however, the lack of adequate input stimuli for the induction of LTP and LTD makes it difficult to study directly the impact of such protocols on behavior. |
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