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Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus |
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| Authors: | Laurence Borgs Pierre Beukelaers Renaud Vandenbosch Laurent Nguyen Gustave Moonen Pierre Maquet Urs Albrecht Shibeshih Belachew and Brigitte Malgrange |
| Institution: | (1) Developmental Neurobiology Unit, Center for Cellular and Molecular Neurobiology, University of Li?ge, C.H.U. B36, 4000 Li?ge, Belgium;(2) Department of Neurology, C.H.U. Sart Tilman, B35, 4000 Li?ge, Belgium;(3) Cyclotron Research Center, University of Li?ge, B30, 4000 Li?ge, Belgium;(4) Department of Medicine, Division of Biochemistry, University of Fribourg, Friboug, Switzerland |
| Abstract: | BackgroundNewborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and neurogenesis in the adult DG. |
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