The di-iron subsite of all-iron hydrogenase: mechanism of cyanation of a synthetic [2Fe3S]-carbonyl assembly |
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Authors: | George SimonJ Cui Zhen Razavet Mathieu Pickett Christopher J |
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Institution: | Department of Biological Chemistry, John Innes Centre, Norwich, UK. |
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Abstract: | This paper describes the kinetics and intimate mechanisms associated with cyanation of 2Fe3S] assemblies to give species structurally related to the subsite of all-iron hydrogenase. Stopped-flow FTIR spectroscopy has enabled the quantitation of the dynamics of five well-defined steps that experimentally illustrate the role of bridging carbonyls in the assembly of the dicyanide species, how on-off sulfur ligation can have a dramatic effect on cyanation kinetics and how the 2Fe3S] core stabilises bridging carbonyl species. |
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