Synthesis of the bicyclic core of the nucleoside antibiotic octosyl acid A |
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| Authors: | More Jesse D Finney Nathaniel S |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. |
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| Abstract: | The bicyclic core of octosyl acid A has been prepared using a diastereoselective acetylide addition and 6-endo selenoetherification as key steps. A detailed study of the selenoetherification reaction and difficulties encountered in the conversion of a phenyl group to a carboxylic acid will be discussed. |
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