Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates |
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Authors: | Zhao Peng Jin Hong-Wei Yang Zhen-Jun Zhang Liang-Ren Zhang Li-He |
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Institution: | State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, China. |
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Abstract: | Four types of beta-carboline-nucleoside conjugates were synthesized. The binding affinities of these beta-carboline-nucleoside conjugates , and to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates and are stronger binders than the parent compound . Computer modeling indicates that the beta-carboline-nucleoside conjugate can fit to the UCU three-nucleotide bulge region of TAR RNA. |
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