Aberrant resting-state cerebral blood flow and its connectivity in primary dysmenorrhea on arterial spin labeling MRI |
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| Institution: | 1. Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, People''s Republic of China,;2. School of Acupuncture Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, People''s Republic of China;3. Traditional Chinese Medicine Center, The First Affiliated Hospital of Henan University of TCM, Henan 453000, People''s Republic of China;4. Acupuncture Department, Yanshan Hospital, Beijing 102500, People''s Republic of China;5. Beijing International Center for Mathematical Research, Peking University, Beijing 100871, People''s Republic of China;2. Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Department of Medical Imaging, First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, China 710061;2. Department of Respiratory and Critical Care Medicine, First affiliated hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, China 710061;1. Department of Neurorehabilitation / TBI-unit, Rigshospitalet, University of Copenhagen, Kette Gaard Alle 30, 2650 Hvidovre, Denmark;2. Department of Clinical Medicine, Faculty of Healthcare Sciences, University of Copenhagen, Denmark;3. Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, Denmark;4. Department of Biostatistics, University of Copenhagen, Denmark;5. Department of Biomedical Sciences, University of Copenhagen, Denmark;6. Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Denmark;7. Section for Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Denmark |
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| Abstract: | PurposeThis study aimed to clarify the resting-state cerebral blood flow alteration patterns induced by primary dysmenorrhea, investigate the relationships between cerebral blood flow alterations and clinical parameters of patients with primary dysmenorrhea, and explore whether brain regions with abnormal cerebral blood flow also feature functional connectivity changes.MethodsArterial spin labeling imaging and clinical parameters were acquired in 42 patients with primary dysmenorrhea and 41 healthy controls during their menstrual phases. Differences in cerebral blood flow were compared between the two groups, and the clusters with significant group differences were selected as the regions of interest for further statistical analyses.ResultsCompared to healthy controls, patients with primary dysmenorrhea exhibited increased cerebral blood flow in the bilateral precuneus, left posterior cingulate cortex, and right rolandic operculum. Among patients with primary dysmenorrhea, we identified a negative correlation between the cerebral blood flow in the right rolandic operculum and the visual analogue score for anxiety, and greater correlation between the functional connectivity in the precuneus/posterior cingulate cortex and the right middle cingulate cortex, and between the right rolandic operculum and the left inferior parietal lobule and the bilateral postcentral gyrus.DiscussionCerebral blood flow abnormalities associated with primary dysmenorrhea were mainly concentrated in the areas comprising the default mode network in primary dysmenorrhea patients, which could be involved in the central mechanism of primary dysmenorrhea. Cerebral blood flow alteration in the rolandic operculum may underlie an anxiety-induced compulsive tendency in patients with primary dysmenorrhea. Investigating the enhanced connectivity among various pain-related brain regions could improve understanding of the onset and development of primary dysmenorrhea. |
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