An individual-based modeling framework for infectious disease spreading in clustered complex networks

We introduce an individual-based model with dynamical equations for susceptible-infected-susceptible (SIS) epidemics on clustered networks. Linking the mean-field and quenched mean-field models, a general method for deriving a cluster approximation for three-node loops in complex networks is proposed. The underlying epidemic threshold condition is derived by using the quasi-static approximation. Our method thus extends the pair quenched mean-field (pQMF) approach for SIS disease spreading in unclustered networks to the scenario of epidemic outbreaks in clustered systems with abundant transitive relationships.We found that clustering can significantly alter the epidemic threshold, depending nontrivially on topological details of the underlying population structure. The validity of our method is verified through the existence of bounded solutions to the clustered pQMF model equations, and is further attested via stochastic simulations on homogeneous small-world artificial networks and growing scale-free synthetic networks with tunable clustering, as well as on real-world complex networked systems. Our method has vital implications for the future policy development and implementation of intervention measures in highly clustered networks, especially in the early stages of an epidemic in which clustering can decisively alter the growth of a contagious outbreak.