In vivo multiparametric magnetic resonance imaging study for differentiating the severity of hepatic warm ischemia-reperfusion injury in a rabbit model |
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| Affiliation: | 1. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands;3. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX;4. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX;5. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI;6. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China;2. Department of Anaesthesia, The Second Affiliated Hospital of Dalian Medical University, Dalian, China;1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore;2. NUS Environmental Research Institute, 5A Engineering Drive 1, T-Lab Building, Singapore 117411, Singapore;3. Shenzhen Engineering Laboratory for Eco-efficient Polysilicate Materials, School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, P.R.C. 518055;1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi Higashi-ku, Fukuoka, 812-8582, Japan;2. Philips Electronics Japan, Philips Bldg., 2-13-37, Kohnan Minato-ku, Tokyo 108-8507, Japan;1. Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China;2. General Surgery Department, The Second Hospital of Shenzhen Baoan People''s Hospital Group, Shenzhen 518108, Guangdong Province, China |
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| Abstract: | ObjectivesTo assess the value of multiparametric magnetic resonance imaging including intravoxel incoherent motion (IVIM), diffusion tensor imaging (DTI) and blood oxygen level dependent (BOLD) MRI in differentiating the severity of hepatic warm ischemia-reperfusion injury (WIRI) in a rabbit model.MethodsFifty rabbits were randomly divided into a sham-operation group and four test groups (n = 10 for each group) according to different hepatic warm ischemia times. IVIM, DTI and BOLD MRI were performed on a 3 T MR scanner with 11 b values (0 to 800 s/mm2), 2 b values (0 and 500 s/mm2) on 12 diffusion directions, multiple-echo gradient echo (GRE) sequences (TR/TE, 75/2.57–24.25 ms), respectively. IVIM, DTI and BOLD MRI parameters, hepatic biochemical and histopathological parameters were compared. Pearson and Spearman correlation methods were performed to assess the correlation between these MRI parameters and laboratory parameters. Furthermore, receiver operating characteristic (ROC) curves were compiled to determine diagnostic efficacies.ResultsTrue diffusion (Dslow), pseudodiffusion (Dfast), perfusion fraction (PF), mean diffusivity (MD) significantly decreased, while R2* significantly increased with prolonged warm ischemia times, and significant differences were found in all of biochemical and histopathological parameters (all P < 0.05). Dslow, PF, and R2* correlated significantly with all of biochemical and histopathological parameters (all |r| = 0.381–0.746, all P < 0.05). ROC analysis showed that the area under the ROC curve (AUC) of IVIM across hepatic WIRI groups was the largest among IVIM, DTI and BOLD.ConclusionsMultiparametric MRI may be helpful with characterization of early changes and determination of severity of hepatic WIRI in a rabbit model. |
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