Synthesis and coating methods of biocompatible iron oxide/gold nanoparticle and nanocomposite for biomedical applications |
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| Institution: | 1. Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in MolecularMedicine (INFORMM), Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia;2. Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia;1. Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran;2. General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium;3. US oncology Inc., Cincinnati, OH, USA;4. Zahedan University of Medical Sciences (ZaUMS), Zahedan, Iran;1. College of Physics, Jilin Normal University, Siping 136000, China;2. Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun 130103, China;3. Technology Development Department, GLOBALFOUNDRIES (Singapore) Pte. Ltd., 60 Woodlands Industrial Park D, Street 2, Singapore 738406, Singapore;4. School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China;5. School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China;6. United Microelect Corp. Ltd., 3 Pasir Ris Dr 12, Singapore 519528, Singapore;1. Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia;2. Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia;1. University School of Basic and Applied Sciences, Guru Gobind Singh Indraprastha University, Sector 16-C, Dwarka, New Delhi 110078, India;2. National Physical Laboratory, Dr K.S. Krishnan Road, New Delhi 110012, India |
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| Abstract: | This detailed review presents an overview of current research on the synthesis, surface modification, and applications of Iron oxide (Fe3O4) nanoparticles and iron oxide/gold (Fe3O4/Au) nanocomposites. The different synthesis techniques of Fe3O4 with various basic organic and inorganic modifications are presented. The applicability and role of inorganic and organic coating on iron oxide/gold core/shell schemes were explored. The trade-off between choices for surface functionalization related to specific applications such as imaging contrast agent, drug delivery carrier and therapeutic device using iron oxide/gold core/shell was also elaborated. The versatility of combining iron oxide/ and gold as nanocomposite as the choice for biomedical application is demonstrated in MRI, CT scan, drug delivery, biosensors, and hyperthermia application. |
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