Towards safe operation of an active retinal prosthesis during functional MRI and diffusion tensor imaging |
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| Institution: | 1. Division of Cardiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA;2. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA;1. CNRS UMR5220; CREATIS Laboratory, University of Lyon, Inserm U1044, INSA-Lyon, Université Lyon 1; Hospices Civils de Lyon, France;2. University of Lyon, Department of Radiology, Hospices Civils de Lyon, France;3. University of Lyon, Department of Vascular Neurology, Hospices Civils de Lyon, France;4. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;5. University of Lyon, Department of Vascular Surgery, Hospices Civils de Lyon, France |
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| Abstract: | ObjectiveTo determine if the Argus II retinal prosthesis can operate during functional MRI (fMRI) and diffusion tensor imaging (DTI) acquisitions and if currents induced in the prosthesis by imaging are at safe levels.Materials and methodsOne Argus II retinal prosthesis was modified to enable current measurements during imaging. Active electronics were modified to enable operation during scans. Induced current was measured during diagnostic scans, which were previously shown to be safe for implanted patients, and during fMRI and DTI scans. All measurements were performed using an ASTM phantom to ensure reproducible placement.ResultsThe prosthesis was able to maintain communication with the external RF coil during the fMRI and DTI scans except briefly during pre-scans. Current levels induced during fMRI and DTI scans were consistently below those measured during diagnostic scans.ConclusionsfMRI and DTI may be safely performed while the Argus II retinal prosthesis is operating. |
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