Gadolinium-doped carbon quantum dots loaded magnetite nanoparticles as a bimodal nanoprobe for both fluorescence and magnetic resonance imaging |
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| Institution: | 1. Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences (Deemed-to-be University), Coimbatore 641114, Tamil Nadu, India;2. Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed-to-be University), Coimbatore 641114, Tamil Nadu, India;1. Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, Tehran, Iran;2. Department of Marine Living Science, Ocean Science Research Center, Iranian National Institute for Oceanography and Atmospheric Science, Tehran, Iran;3. Department of Chemistry, Shahid Beheshti University, Tehran, Iran;1. Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei 10607, Taiwan;2. Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan;3. Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan;4. Department of Chemistry, Shivaji University, Kolhapur, Maharashtra 416004, India;5. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan;6. School of Dentistry, College of Medicine, China Medical University, Taichung 404, Taiwan;7. 3D Global Biotechnology Inc., New Taipei City 221, Taiwan;8. Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, New Taipei City 235, Taiwan;1. Institute of Medical Imaging and Digital Medicine, School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, China;2. Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, China;1. Fine Dust Research Department, Korea Institute of Energy Research (KIER), 152 Gajeong-ro, Yuseong-gu, Daejeon 34129, Republic of Korea;2. Department of Advanced Energy and Technology, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea;3. Chemical Engineering Pilot Plant Department, Engineering Research division, National Research Centre, Cairo 12622, Egypt;4. Department of Chemical and Biological Engineering, Hanbat National University, 125 Dongseodero, Yuseong-gu, Daejeon 34158, Republic of Korea |
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| Abstract: | Nowadays, it is highly desired to develop dual-modal fluorescence and magnetic resonance imaging (FI/MRI) probes in medical imaging because it unites the respective advantages of each imaging modality: high sensitivity of FI and superior spatial resolution of MRI. In this study, a facile strategy to fabricate a new bimodal imaging nanoprobe (Gd-CQDs@N-Fe3O4) was reported by integrating the fluorescence ability of carbon quantum dots (CQDs) and T1 and T2 contrast-enhancing functionality of Gd(III) ions and Fe3O4 nanoparticles into a single hybrid nanostructure. The hybrid composites were investigated by FT-IR, XRD, TEM, XPS, VSM, and so on, which confirmed that Gd-CQDs@N-Fe3O4 nanoparticles were successfully obtained and exhibited superparamagnetic property at room temperature. The derived nanoprobes presented an excitation wavelength-independent emission behavior. In addition, r1 and r2 relaxivities of the synthesized imaging nanoprobes were measured to be 5.16 and 115.6 mM−1 s−1, which nominated Gd-CQDs@N-Fe3O4 nanocomposites as a suitable T1-T2 contrast agent. The Gd-CQDs@N-Fe3O4 nanoparticles combining two synergetic imaging modalities showed great potential in FI/MRI dual-modal imaging for a more complementary and accurate detection. |
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