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Longitudinal changes in HIV-specific IFN-γ secretion in subjects who received Remune™ vaccination prior to treatment interruption |
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| Authors: | Kenneth H Huang Marie-Pierre Boisvert Famane Chung Maude Loignon Don Zarowny Lise Cyr Emil Toma Nicole F Bernard |
| Institution: | 1. McGill University Health Centre, Montreal, Quebec, Canada 2. Centre hospitalier de l'Université de Montreal, Montreal, Quebec, Canada 3. Canadian HIV Trials Network, Vancouver, British Colombia, Canada |
| Abstract: | BackgroundDespite the benefits of highly active antitretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during treatment interruption (TI). This study explored whether HAART intensification with Remune™ vaccination before TI can boost HIV-1-specific immunity, leading to improved control of viremia off HAART. |
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