An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore |
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| Authors: | Baker J R Thominet O Britton H Caddick S |
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| Institution: | Department of Chemistry, Christopher Ingold Laboratories, University College London, 20 Gordon Street, London WC1H OAJ, United Kingdom. |
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| Abstract: | reaction: see text] A key structural feature of the Neocarzinostatin chromophore is a reactive epoxydiyne. We present here a new method for the preparation of epoxydiynes by the addition of an allenyl zinc bromide to a propargylic ketone. |
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