The mechanism of Sandmeyer's cyclization reaction by electrospray ionization mass spectrometry |
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Authors: | Silva Bárbara V Violante Flávio A Pinto Angelo C Santos Leonardo S |
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Institution: | Instituto de Química-CT, Bloco A, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21941-970, Rio de Janeiro, RJ, Brazil. |
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Abstract: | Using electrospray ionization (tandem) mass spectrometry (ESI-MS(/MS)) spectrometric experiments, the Sandmeyer reaction was monitored on-line, and key intermediates were intercepted and characterized for the first time. The mechanistic information provided by on-line ESI-MS(/MS) is in accordance with Sandmeyer's proposal, and was made possible by coupling a microreactor on-line to the ESI ion source, which allowed reactions to be screened from 0.7-2.0 s, identifying and characterizing all intermediates that were formed and consumed during the reaction. |
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