| 卡尔-费休滴定法测定有机锌盐药物中水分 |
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| 引用本文： | 何新蕾,郝二军,程传玲,徐桂清,李伟,胡志国.卡尔-费休滴定法测定有机锌盐药物中水分[J].理化检验(化学分册),2011(3). |
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| 作者姓名： | 何新蕾 郝二军 程传玲 徐桂清 李伟 胡志国 |
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| 作者单位： | 河南师范大学化学与环境科学学院;漯河医学高等专科学校;郑州轻工业学院食品与生物工程学院; |
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| 基金项目： | 国家“863”计划资助项目(2004AAZZ3190); 河南师范大学新引进博、硕士科研启动支持课题资助项目(No.522038) |
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| 摘 要： | 采用卡尔-费休滴定法测定有机锌盐药物中水分时,改用甲醇-氨溶液(质量比180比1)作溶剂溶解试样。改进的溶剂利于有机锌盐药物的溶解及结晶水的释放。试验结果表明:有机锌盐药物中水分的测定值比药典法测定值高,相对标准偏差(n=5)在0.13%～0.36%之间。
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| 关 键 词： | 卡尔-费休滴定法 有机锌盐药物 水分 |
Determination of Moisture in Organic Zinc Drugs by Karl-Fischer Titration |
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| HE Xin-lei,HAO Er-jun,CHENG Chuan-ling,XU Gui-qing,LI Wei,HU Zhi-guo.Determination of Moisture in Organic Zinc Drugs by Karl-Fischer Titration[J].Physical Testing and Chemical Analysis Part B:Chemical Analgsis,2011(3). |
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| Authors: | HE Xin-lei HAO Er-jun CHENG Chuan-ling XU Gui-qing LI Wei HU Zhi-guo |
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| Institution: | HE Xin-lei~(1,2),HAO Er-jun~(1*),CHENG Chuan-ling~3,XU Gui-qing~1,LI Wei~1,HU Zhi-guo~1 (1.College of Chem.and Environmental Science,Henan Normal University,Xinxiang 453002,China,2.Luohe Medical College,Luohe 462002,3.Dept.of Food and Biological Eng.,Zhengzhou College of Light Industry,Zhengzhou 450002,China) |
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| Abstract: | In the Karl-Fischer titrimetric determination of moisture in drugs of organic zinc salts,a modification was made by dissolving the sample with CH_3OH-NH_3(180+1 by mass) solution.It was found that the sample was easier to be dissolved and its water of crystallization was completely released by using this solvent.In analyzing 9 drug samples by the proposed method,results obtained were higher than those obtained by the pharmacopeial method.Values of RSD's(n = 5) found were in the range of 0.13%-0.36%. |
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| Keywords: | Karl-Fischer titration Organic zinc drugs Moisture |
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