| 稀土甲基磺酸盐催化苯乙酮、芳香醛和芳香胺的Mannich反应 |
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| 引用本文： | 宋志国,王敏,姜恒,肖振林. 稀土甲基磺酸盐催化苯乙酮、芳香醛和芳香胺的Mannich反应[J]. 合成化学, 2009, 17(6) |
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| 作者姓名： | 宋志国 王敏 姜恒 肖振林 |
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| 作者单位： | 渤海大学科技实验中心,辽宁,锦州,121000;渤海大学化学化工学院,辽宁,锦州,121000;辽宁石油化工大学,辽宁,抚顺,113001 |
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| 基金项目： | 辽宁省教育厅科学技术研究资助项目 |
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| 摘 要： | 室温下,稀土甲基磺酸盐催化苯乙酮、芳香醛和芳香胺的Mannich反应,三组分"一锅法"合成了23种β-氨基酮衍生物(其中4种为新化合物),其结构经~1H NMR,IR和元素分析确证.比较了甲基磺酸镧、亚铈、镨、钕、镱的催化活性,结果表明其催化活性接近;催化剂可重复使用.
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| 关 键 词： | 甲基磺酸盐 Mannich反应 β-氨基酮衍生物 一锅法 |
Rare Earth Methanesulfonate Catalyzed Mannich Reaction of Acetophenone, Aromatic Aldehyde and Aromatic Amine |
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| SONG Zhi-guo,WANG Min,JIANG Heng,XIAO Zhen-lin. Rare Earth Methanesulfonate Catalyzed Mannich Reaction of Acetophenone, Aromatic Aldehyde and Aromatic Amine[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(6) |
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| Authors: | SONG Zhi-guo WANG Min JIANG Heng XIAO Zhen-lin |
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| Abstract: | Twenty-three β-amino ketone derivatives(four new compounds) were synthesized by three components one-pot Mannich reaction of acetophenone, aromatic aldehydes and aromatic amines using rare earth methylsulfonate as the catalyst at room temperature. The structures were characterized by ~1H NMR, IR and elemental analysis. The catalytic activities of La, Ce(Ⅲ), Pr, Nd and Yb methanesulfonates were compared with each other, and the results showed that they possessed similar activities. The catalysts could be recovered and reused many times without distinct loss of their catalytic activities. |
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| Keywords: | methanesulfonate Mannich reaction one-pot synthesis |
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