Structure of 6-aminobenzofuran-2-sulfonamide: A tropically active carbonic anhydrase inhibitor |
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| Authors: | M Datta A K Das S K Mazumdar B Mazumdar S K Talapatra G Bocelli |
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| Institution: | (1) Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Sector I, Block AF, Bidhannagar, 700 064 Calcutta, India;(2) Department of Physics, Jadavpur University, 700 032 Calcutta, India;(3) Centro di Studio per la Strutturistica Diffrattometrica del CNR, Viale delle Scienze, Palazzo Chimico, I-43100 Parma, Italy |
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| Abstract: | Crystals of the title compound are triclinic. Space groupP1,a=8.652(2),b=5.184(2),c=5.050(2)Å, =100.26(3)°, =100.33(4)°,  =72.82(3)°. The structure was solved by direct methods and refined by a full-matrix, least-squares procedure toR=0.033 for 1168 observed I >2 (I)] reflections. The sulfonamide group is at a right angle to the benzofuran ring and the dihedral angle between the benzene and furan ring is 2.0(1)°. In the crystal packing the molecules are linked together by N-H O and N-HN type hydrogen bonds arranging themselves in such a way that there are alternate hydrophobic and hydrophilic regions extended along the a-axis. |
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