Cover Picture: Nanomaterials for Fluorescence and Multimodal Bioimaging (Chem. Rec. 3/2023) |
| |
Authors: | Jeladhara Sobhanan Abdulaziz Anas Vasudevanpillai Biju |
| |
Institution: | 1. Graduate School of Environmental Science, Hokkaido University, N10?W5, Sapporo, Hokkaido, 060-0810 Japan
Department of Chemistry, Rice University, Houston, Texas 77005 United States;2. CSIR-National Institute of Oceanography, Regional Centre Kochi, Kerala, 682 018 India;3. Graduate School of Environmental Science, Hokkaido University, N10?W5, Sapporo, Hokkaido, 060-0810 Japan |
| |
Abstract: | Bioconjugated nanomaterials replace molecular probes in bioanalysis and bioimaging in vitro and in vivo. Nanoparticles of silica, metals, semiconductors, polymers, and supramolecular systems, conjugated with contrast agents and drugs for image-guided (MRI, fluorescence, PET, Raman, SPECT, photodynamic, photothermal, and photoacoustic) therapy infiltrate into preclinical and clinical settings. Small bioactive molecules like peptides, proteins, or DNA conjugated to the surfaces of drugs or probes help us to interface them with cells and tissues. Nevertheless, the toxicity and pharmacokinetics of nanodrugs, nanoprobes, and their components become the clinical barriers, underscoring the significance of developing biocompatible next-generation drugs and contrast agents. This account provides state-of-the-art advancements in the preparation and biological applications of bioconjugated nanomaterials and their molecular, cell, and in vivo applications. It focuses on the preparation, bioimaging, and bioanalytical applications of monomodal and multimodal nanoprobes composed of quantum dots, quantum clusters, iron oxide nanoparticles, and a few rare earth metal ion complexes. |
| |
Keywords: | Bioimaging in?vivo imaging DNA quantum dots fluorescence MRI multimodality intracellular delivery |
|
|