Exploring Guanidinium Organocatalysts for Hypoiodite-Mediated Reactions |
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Authors: | Dr Miami Odagi Prof Dr Kazuo Nagasawa |
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Institution: | Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, 184-8588 Koganei, Tokyo, Japan |
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Abstract: | This account describes our recent work on developing guanidinium hypoiodite- catalysts for oxidative carbon-nitrogen and carbon-carbon bond-forming reactions. These reactions proceeded smoothly using guanidinium hypoiodite generated in situ by treating 1,3,4,6,7-hexahydro-2H-pyrimido1,2-a]pyrimidine hydroiodide salts with an oxidant. In this approach, the ionic interaction and hydrogen bonding ability of the guanidinium cations enable bond-forming reactions that have been difficult with conventional methods. Enantioselective oxidative carbon-carbon bond-forming reaction was also achieved by using a chiral guanidinium organocatalyst. |
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Keywords: | Organocatalyst Guanidinium Hypoiodite Oxidative Functionalization |
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