[(SIPr)Ag(CF2H)]: A Shelf-Stable,Versatile Difluoromethylation Reagent |
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| Authors: | Haiwei Zhao Yang Gu Qilong Shen |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 P. R. China |
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| Abstract: | Due to its unique physical and electrophilic properties, the difluoromethyl group (?CF2H) has been playing an irreplaceable role in the field of pharmaceutical and agrochemical industry. Methods that could efficiently incorporate the difluoromethyl group into the target molecules are increasing in the recent years. Developing a stable and efficient difluoromethylating reagent is thus highly attractive. In this review, we describe the development of a nucleophilic difluoromethylation reagent (SIPr)Ag(CF2H)], including its elemental reaction, difluoromethylation reaction with different types of electrophiles, and its application in the synthesis of a nucleophilic and an electrophilic difluoromethylthiolating reagent. |
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| Keywords: | fluorine difluoromethyl silver reagent nucleophilic |
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