Influence of relative humidity on the electrostatic charging of lactose powder mixed with salbutamol sulphate |
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| Institution: | 1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia;2. CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia;1. TÜV SÜD Process Safety, Basel, Switzerland;2. Swiss Process Safety, Basel, Switzerland |
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| Abstract: | In this study, electrostatic charging of lactose and its mixtures with salbutamol sulphate (SS) were studied as a function of relative humidity (RH). Powder adhesion onto a steel pipe surface was also investigated. The powders were charged by sliding in a steel pipe. Increase in RH decreased the charging of lactose and mixtures, but the effect on SS was not evident. Furthermore, the charge of the mixtures reversed from negative to positive as RH was increased and remained positive as the samples were again dried. Humidification also changed the adhesion behavior of the mixtures onto the pipe surface. |
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| Keywords: | Powder charging Relative humidity Powder mixtures Salbutamol sulphate Lactose |
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