19F-Labeled Probes for Recognition-Enabled Chromatographic 19F NMR |
| |
Authors: | Dr. Zhenchuang Xu Prof. Dr. Yanchuan Zhao |
| |
Affiliation: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 China |
| |
Abstract: | The NMR technique is among the most powerful analytical methods for molecular structural elucidation, process monitoring, and mechanistic investigations; however, the direct analysis of complex real-world samples is often hampered by crowded NMR spectra that are difficult to interpret. The combination of fluorine chemistry and supramolecular interactions leads to a unique detection method named recognition-enabled chromatographic (REC) 19F NMR, where interactions between analytes and 19F-labeled probes are transduced into chromatogram-like 19F NMR signals of discrete chemical shifts. In this account, we summarize our endeavor to develop novel 19F-labeled probes tailored for separation-free multicomponent analysis. The strategies to achieve chiral discrimination, sensitivity enhancement, and automated analyte identification will be covered. The account will also provide a detailed discussion of the underlying principles for the design of molecular probes for REC 19F NMR where appropriate. |
| |
Keywords: | Fluorine chemistry 19F NMR Molecular recognition Chiral discrimination Multicomponent analysis |
|
|