Gram-scale preparation of dialkylideneacetones through Ca(OH)2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH |
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Authors: | Hao Zhang Mengting Han Chenggen Yang Lei Yu Qing Xu |
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Affiliation: | a Guangling College, Yangzhou University, Yangzhou 225002, China;b School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China |
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Abstract: | A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)2 as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level. |
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Keywords: | Claisen-Schmidt condensation Acetone Aldehyde Dialkylideneacetone |
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