Synthesis of 11-aminodrim-7-ene from drimenol |
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Authors: | K I Kuchkova A N Arycu P F Vlad |
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Institution: | (1) Institute of Chemistry, Academy of Sciences of the Republic of Moldova, MD-2028 Kishinev, Moldova |
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Abstract: | 11-Aminodrim-7-ene was synthesized from drimenol in four steps. Drimenol was oxidized into drimenal and its oxime was dehydrated
by p-tosylchloride or acetic anhydride in pyridine to form 9-cyano-11-nordrim-7-ene, reduction of which by LiAlH4 in the presence of anhydrous AlCl3 produced 11-aminodrim-7-ene. The reaction of 9-cyano-11-nordrim-7-ene, NaBH4, and CoCl2·6H2O produced a mixture of drimenylamine and 7,8-dihydrodrimenylamine in a 2:1 ratio.
Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 311–314, May–June, 2009. |
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Keywords: | synthesis drimenol drimenylamine 9-cyano-11-nordrim-7-ene |
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