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Spirolactone syntheses through a rhodium-catalyzed intramolecular C-H insertion reaction: model studies towards the synthesis of syringolides |
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| Authors: | Mauricio Navarro Villalobos John L Wood |
| Institution: | Sterling Chemistry Laboratory, Yale University, New Haven, CT 06520-8107, USA |
| Abstract: | Model studies towards the total synthesis of syringolides using a rhodium-catalyzed intramolecular C-H insertion reaction as the key step are described. A highly stereospecific synthesis of spirolactones is achieved employing this methodology. |
| Keywords: | Syringolides Spirolactones C-H insertion Rhodium(II) stabilized carbene Stereospecific |
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