Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons |
| |
Authors: | Alexander C. Weymouth-Wilson,Daniel Best,Maria-Soledad Pino-Gonzá lez |
| |
Affiliation: | a Dextra Laboratories Ltd, The Science and Technology Centre, Whiteknights Road, Reading RG6 6BZ, UK b Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK c Summit PLC, 91, Milton Park, Abingdon, Oxon OX14 4RY, UK d Departamento de Bioquímica, Biología Molecular y Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain |
| |
Abstract: | 1,2-O-Isopropylidene-α-l-glucurono-3,6-lactone may be synthesized on a 100-200 g scale from cheaply available d-glucoheptonolactone in an overall yield of 94% in four steps via l-glucuronolactone. Subsequent elaboration to l-glucose, diacetone-l-glucose (1,2:5,6-di-O-isopropylidene-α-l-glucofuranose), and monoacetone-l-glucose (1,2-O-isopropylidene-α-l-glucofuranose) allows easy access to a range of l-sugar chirons. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|