Convenient multigram synthesis of monodisperse oligo(ethylene glycols): effective reaction monitoring by infrared spectroscopy using an attenuated total reflection fibre optic probe |
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Authors: | Daniel Lumpi Christian Hametner Bernhard Zachhuber Johannes Fröhlich |
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Institution: | a Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria b Institute of Chemical Technologies and Analytics, Vienna University of Technology, 1060 Vienna, Austria |
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Abstract: | A convenient approach for the synthesis of monodisperse oligo(ethylene glycols) up to 12 units is described. A novel cleavage protocol replacing laborious hydrogenolysis is introduced to achieve a fast, inexpensive and widely applicable procedure. In addition to the synthetic part, Fourier transform infrared (FTIR) spectroscopy using a fibre optic attenuated total reflection (ATR) sensor was applied to monitor the formation of sensitive key intermediates, resulting in optimized reaction times. By applying this in-line technique, the possibility of real-time analysis under inert conditions was impressively demonstrated. |
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Keywords: | Monodisperse OEG PEG Trityl cleavage Oligo(ethylene glycols) In situ reaction monitoring ATR-IR-sensor spectroscopy |
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