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Lycopladine H, a novel alkaloid with fused-tetracyclic skeleton from Lycopodium complanatum
Authors:Kan’ichiro Ishiuchi  Shigeki Hayashi  Jun’ichi Kobayashi
Institution:a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
b Hokkaido Division, Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Nayoro 096-0065, Japan
Abstract:A novel Lycopodium alkaloid, lycopladine H (1), with a fused-tetracyclic ring system consisting of an azocane ring connected to a 2,2,2]-bicyclooctane ring and a 3-piperidone ring, was isolated from the club moss Lycopodium complanatum. The structure and relative stereochemistry of 1 were elucidated on the basis of spectroscopic data.
Keywords:Lycopodium alkaloid  Lycopodium complanatum  Lycopladine H
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