Di(ethylene glycol) vinyl ether: a highly efficient deactivating reagent for olefin metathesis catalysts |
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| Authors: | Weidong Liu Paul J. Nichols |
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| Affiliation: | a Department of Process Chemistry, Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States
b University of Colorado at Boulder, Boulder, CO 80309, United States |
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| Abstract: | A highly efficient method for deactivating commonly used olefin metathesis catalysts is described. Inexpensive and commercially available di(ethylene glycol) vinyl ether is found to quench both first- and second-generation Grubbs’ carbenes in less than 10 min at room temperature. The resulting ruthenium byproducts are readily removed by silica gel purification. |
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| Keywords: | Metathesis Scavenger RCM Fisher carbene Ruthenium |
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