Stereoselective synthesis of the densely functionalized C1-C9 fragment of amphidinolides C and F |
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| Authors: | Debendra K Mohapatra Pavankumar Dasari Rita Pal |
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| Institution: | a Organic Chemistry Division-I, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 007, India
b Organic Chemistry Division, National Chemical Laboratory (CSIR), Pune 411 008, India |
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| Abstract: | The synthesis of the C1-C9 subunit of amphidinolides C and F is described. Key steps include tandem Sharpless asymmetric dihydroxylation-SN2 cyclization reaction, Lewis acid-mediated epoxide opening, Wittig reaction, and Wacker oxidation. |
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| Keywords: | Amphidinolide C and F Cytotoxic Tandem dihydroxylation-SN2 Wittig reaction Wacker oxidation |
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