A simple one-pot synthesis of triflyl guanidines: access to highly substituted electron-poor guanidines |
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Authors: | Karen Thai |
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Institution: | Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Canada SK S7N 5C9 |
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Abstract: | Unsymmetrical di- and trisubstituted triflyl guanidines are accessed through a simple, one-pot protocol from the corresponding isothiocyanate and amine. Furthermore, in the presence of base, trisubstituted triflyl guanidines are alkylated to obtain tetrasubstituted triflyl guanidines in high yields and complete regioselectivity. |
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Keywords: | Guanidines Isothiocyanates Trifluoromethanesulfonamide Regioselective alkylation |
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