A mild, one-pot preparation of 1,3,4-oxadiazoles |
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Authors: | Changkun Li |
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Institution: | Department of Chemistry, HCV DPU, Infectious Diseases CEDD, GlaxoSmithKline, Research Triangle Park, NC 27709, USA |
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Abstract: | A mild and efficient one-pot protocol for the synthesis of 1,3,4-oxadiazoles from carboxylic acids and acylhydrazides was developed. Diacylhydrazide formation via HATU coupling followed by addition of Burgess reagent afforded the corresponding 1,3,4-oxadiazoles in 63-96% yields at room temperature. The reaction conditions are tolerant of a variety of functional groups, including esters, nitriles, alkynes, olefins, alkyl halides, phenols, carbamates and sulfonamides. |
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