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2-Aryl propionamides via 1,4-aryl radical migration from N-arylsulfonyl-2-bromopropionamides |
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| Authors: | Andrew J. Clark Stuart R. Coles Alana Collis David R. Fullaway Nicholas P. Murphy Paul Wilson |
| Affiliation: | Department of Chemistry, University of Warwick, Coventry, West Midlands CV4 7AL, United Kingdom |
| Abstract: | Reaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides via initial radical generation, 1,4-aryl migration with loss of SO2 and reduction of the intermediate amidyl radical in 40-99% yields. |
| Keywords: | Copper ATRC Atom transfer Radical Aryl migration Dimethylpiperazine |
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