NMR Studies of Drugs. Phensuximide. 1H and 13C NMR Methods with Chiral Solvating Agents and Lanthanide Shift Reagents |
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| Authors: | Robert Rothchild Kerry Sanders Kunisi S. Venkatasubban |
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| Affiliation: | 1. The City University of New York, John Jay College of Criminal Justice, Science Department, Toxicology Research and Training Center , 445 West 59th Street, New York, NY, 10019-1199;2. University of North Florida, Department of Natural Sciences , Jacksonville, FL, 32216 |
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| Abstract: | NMR spectra of the racemic anticonvulsant, phensuximide, 1, in CDCl3 solution, have been studied with additives to explore methods for potential direct determination of enantiomeric excess (% ee). Proton studies at 200 MHz with the chiral solvating agent (CSA) (-)-2,2,2-trifluoro-1- (9-recommended for ee analysis due to uncertainties of contributions to the NCH3 from the CH2 proton absorptions. |
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| Keywords: | Optical purity Enantiomeric excess Analysis Stereoisomers LSR CSA Anticonvulsant 2,2,2-Trifluoro-1- (9-anthryl) ethanol TFAE Eu (FOD)3 Eu (HFC)3 Europium 1-Methyl-3-phenyl-2,5-pyrrolidinedione |
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