NMR Studies of Drugs. Phensuximide. 1H and 13C NMR Methods with Chiral Solvating Agents and Lanthanide Shift Reagents |
| |
| Authors: | Robert Rothchild Kerry Sanders Kunisi S Venkatasubban |
| |
| Institution: | 1. The City University of New York, John Jay College of Criminal Justice, Science Department, Toxicology Research and Training Center , 445 West 59th Street, New York, NY, 10019-1199;2. University of North Florida, Department of Natural Sciences , Jacksonville, FL, 32216 |
| |
| Abstract: | NMR spectra of the racemic anticonvulsant, phensuximide, 1, in CDCl3 solution, have been studied with additives to explore methods for potential direct determination of enantiomeric excess (% ee). Proton studies at 200 MHz with the chiral solvating agent (CSA) (-)-2,2,2-trifluoro-1- (9-recommended for ee analysis due to uncertainties of contributions to the NCH3 from the CH2 proton absorptions. |
| |
| Keywords: | Optical purity Enantiomeric excess Analysis Stereoisomers LSR CSA Anticonvulsant 2 2 2-Trifluoro-1- (9-anthryl) ethanol TFAE Eu (FOD)3 Eu (HFC)3 Europium 1-Methyl-3-phenyl-2 5-pyrrolidinedione |
|
|
